KF-20444
KF-20444 is an orally active ALK inhibitor with blood-brain barrier penetration. KF-20444 exhibits strong inhibitory activity against ALK fusion proteins (EML4-ALK) and ALK resistance mutations (including L1196M, G1202R, and F1174L) . KF-20444 effectively suppresses the phosphorylation of ALK in ALK-driven cancer cell lines, thereby inhibiting cancer cell proliferation and inducing apoptosis. KF-20444 demonstrates anti-tumor efficacy in mouse models bearing ALK-positive non-small cell lung cancer (NSCLC) or neuroblastoma. KF-20444 can be used for the study of ALK-driven malignancies[1].
Product Specifications
CAS Number
[154015-73-3]
UNSPSC
12352005
Target
Anaplastic lymphoma kinase (ALK) ; Apoptosis
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=C(C1=C2CCCC3=C(C=CC(C4=C(F)C=CC=C4)=C3)C2=NC5=C1C=C(C=C5)F)O
Molecular Formula
C25H17F2NO2
Molecular Weight
401.40
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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