PD 175069

PD 175069 is a potent and selective N-type calcium channel antagonist with an IC50 of 0.32 μM. PD 175069 is efficacious in an audiogenic seizure model using DBA/2 mice. PD 175069 can be used for research on neurological conditions such as neuropathic pain and stroke[1].

Product Specifications

CAS Number

[217170-95-1]

UNSPSC

12352005

Target

Calcium Channel

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Smiles

CC(C)CCN(C)[C@@H](CC(C)C)C(N[C@H](C(NC(C)(C)C)=O)CC1=CC=C(OCC2=CC=CC=C2)C=C1)=O

Molecular Formula

C32H49N3O3

Molecular Weight

523.75

References & Citations

[1]Hu LY, et al. Synthesis and biological evaluation of substituted 4- (OBz) phenylalanine derivatives as novel N-type calcium channel blockers. Bioorg Med Chem Lett. 1999 Apr 19;9 (8) :1121-6.