GI-129471

GI-129471 is a MMP inhibitor. GI-129471 exhibits inhibitory activity against cancer cell invasion. GI-129471 can completely block the enhanced production of IgE and IgG1 by mouse B cells induced by rat mast cell protease-I (RMCP-I) . GI-129471 can be used for the study of cancer and mast cell chymase-regulated immunological processes[1][2].

Product Specifications

CAS Number

[130370-59-1]

UNSPSC

12352005

Target

MMP

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Smiles

ONC([C@@H](CSC1=CC=CC=C1)[C@@H](CC(C)C)C(N[C@H](C(NC)=O)CC2=CC=CC=C2)=O)=O

Molecular Formula

C25H33N3O4S

Molecular Weight

471.61

References & Citations

[1]Kempen I, et al. 3-Bromophenyl 6-acetoxymethyl-2-oxo-2H-1-benzopyran-3-carboxylate inhibits cancer cell invasion in vitro and tumour growth in vivo. Br J Cancer. 2003 Apr 7;88 (7) :1111-8. |[2]Yoshikawa T, et al. Rat mast cell protease-I enhances immunoglobulin E production by mouse B cells stimulated with interleukin-4. Immunology. 2001 Nov;104 (3) :333-40.