CP-288886
CP-288886 is a cysLT1 receptor antagonist with a Ki value of 0.004 μM. CP-288886 exhibits comparable activity to Zafirlukast (HY-17492) and Pranlukast (HY-B0290) . CP-288886 inhibits calcium mobilization with an IC50 of 0.0005 μM in human U937 cells. CP-288886 has high oral bioavailability. CP-288886 possesses anti-asthmatic activity in a guinea pig asthma model and can be used for the research of diseases such as asthma[1].
Product Specifications
CAS Number
[221332-74-7]
UNSPSC
12352005
Target
Calcium Channel; Leukotriene Receptor
Related Pathways
GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Inflammation/Immunology
Smiles
O[C@H]1C2=CC(OCC3=NC4=CC(Cl)=CC=C4C=C3)=CC=C2OC(C)(C)[C@H]1CC5=C(C=CC(NS(C(F)(F)F)(=O)=O)=C5)OC
Molecular Formula
C30H28ClF3N2O6S
Molecular Weight
637.07
References & Citations
[1]Chambers RJ, et al. Development of 2,2-dimethylchromanol cysteinyl LT1 receptor antagonists. Bioorg Med Chem Lett. 1998 Dec 15;8 (24) :3577-82.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
LTD4/CysLT1
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