UK 343664

UK 343664 is a potent, orally active and selective PDE5 inhibitor. UK 343664 partially reverses Thromboxane-induced pulmonary hypertension[1][2].

Product Specifications

CAS Number

[215297-27-1]

UNSPSC

12352005

Target

Phosphodiesterase (PDE)

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cardiovascular Disease

Smiles

O=C1N=C(C2=C(OCCC)C=CC(S(=O)(N3CCN(CC3)CC)=O)=C2)NC4=C(CC)N(CC5=NC=CC=C5)N=C41

Molecular Formula

C28H35N7O4S

Molecular Weight

565.69

References & Citations

[1]Walker DK, et al. Pharmacokinetics and metabolism of a selective PDE5 inhibitor (UK-343,664) in rat and dog. Xenobiotica. 2001 Aug-Sep;31 (8-9) :651-64. |[2]Urdaneta F, et al. Effects of a new phosphodiesterase enzyme type V inhibitor (UK 343-664) versus milrinone in a porcine model of acute pulmonary hypertension. Ann Thorac Surg. 2004 Oct;78 (4) :1433-7.