Dilopetine (citrate)

Dilopetine citrate is an inhibitor of substance P release. Dilopetine citrate dose-dependently reduces the vocalizing of isolated guinea pig pups. Dilopetine citrate shows good activity as an antidepressant[1][2].

Product Specifications

CAS Number

[247046-64-6]

Product Name Alternative

E-6006 (citrate)

UNSPSC

12352005

Target

Neurokinin Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

OC(CC(C(O)=O)(O)CC(O)=O)=O.CN(C)CCOC(C1=CC=CS1)C2=CC=NN2C

Molecular Formula

C19H27N3O8S

Molecular Weight

457.50

References & Citations

[1]Gómez-Gomar A, et al. Enantioseparation of basic pharmaceutical compounds by capillary electrophoresis using sulfated cyclodextrins. Application to E-6006, a novel antidepressant. J Chromatogr A. 2003 Mar 21;990 (1-2) :91-8.|[2]Hennessy MB, et al. Effects of a novel potential antidepressant on the behavior and cortisol levels of isolated guinea pig pups. Pharmacol Biochem Behav. 2001 Jul-Aug;69 (3-4) :527-33.