S-14489

S-14489 is an orally active selective postsynaptic 5-HT1A receptor antagonist with a pKi of 9.2. S-14489 can act as a 5-HT1A autoreceptor agonist and inhibit striatal 5-hydroxytryptophan accumulation. S-14489 can be used for the research of neurological disease[1].

Product Specifications

CAS Number

[153607-44-4]

UNSPSC

12352005

Target

5-HT Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

C12=CC=CC(N3CCN(CCC4C5=C(C4)C=CC=C5)CC3)=C1OCCO2

Molecular Formula

C22H26N2O2

Molecular Weight

350.45

References & Citations

[1]Millan MJ, et al. Novel benzodioxopiperazines acting as antagonists at postsynaptic 5-HT1A receptors and as agonists at 5-HT1A autoreceptors: a comparative pharmacological characterization with proposed 5-HT1A antagonists. J Pharmacol Exp Ther. 1994 Jan;268 (1) :337-52.