CGS-30440
CGS-30440 is a potent and orally active dual inhibitor of neutral endopeptidase (NEP) and angiotensin-converting enzyme (ACE) . CGS-30440 exhibit antihypertensive and natriuretic effects. CGS-30440 also shows protective effect for chronic renal failure. CGS-30440 can be used for the research of cardiovascular disease, such as hypertension[1][2].
Product Specifications
CAS Number
169319-62-4
UNSPSC
12352005
Target
Angiotensin-converting Enzyme (ACE) ; Neprilysin
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cardiovascular Disease
Smiles
COC(C=C1)=CC=C1C[C@@H](C(OCC)=O)NC(C2(CCCC2)NC([C@H](C(C)C)SC(C)=O)=O)=O
Molecular Formula
C25H36N2O6S
Molecular Weight
492.63
References & Citations
[1]Webb RL, et al. Effects of the novel dual inhibitor of neutral endopeptidase and angiotensin-converting enzyme, CGS 30440, on blood pressure and cardiac hypertrophy in spontaneously hypertensive rats. J Cardiovasc Pharmacol. 1997 Nov;30 (5) :632-42.|[2]Cohen DS, et al. Protective effects of CGS 30440, a combined angiotensin-converting enzyme inhibitor and neutral endopeptidase inhibitor, in a model of chronic renal failure. J Cardiovasc Pharmacol. 1998 Jul;32 (1) :87-95.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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