NSC 727357
NSC 727357 is a DNA intercalator and topoisomerase inhibitor with antitumor activity. NSC 727357 can inhibit cells proliferation and induce G1 phase arrest. NSC 727357 can be used for the research of cancer, such as melanoma[1].
Product Specifications
CAS Number
910229-23-1
UNSPSC
12352005
Target
DNA/RNA Synthesis; Topoisomerase
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
O=C1N(C2=C(C(C3=CC=CC=C23)=O)C4=CC=CC=C41)CCCNCCCNCCCN5C6=C(C(C7=CC=CC=C67)=O)C8=CC=CC=C8C5=O
Molecular Formula
C41H36N4O4
Molecular Weight
648.75
References & Citations
[1]Antony S, et al. Bisindenoisoquinoline bis-1,3-{ (5,6-dihydro-5,11-diketo-11H-indeno[1,2-c]isoquinoline) -6-propylamino}propane bis (trifluoroacetate) (NSC 727357), a DNA intercalator and topoisomerase inhibitor with antitumor activity. Mol Pharmacol. 2006 Sep;70 (3) :1109-20.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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