NSC 727357

NSC 727357 is a DNA intercalator and topoisomerase inhibitor with antitumor activity. NSC 727357 can inhibit cells proliferation and induce G1 phase arrest. NSC 727357 can be used for the research of cancer, such as melanoma[1].

Product Specifications

CAS Number

[910229-23-1]

UNSPSC

12352005

Target

DNA/RNA Synthesis; Topoisomerase

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Cancer

Smiles

O=C1N(C2=C(C(C3=CC=CC=C23)=O)C4=CC=CC=C41)CCCNCCCNCCCN5C6=C(C(C7=CC=CC=C67)=O)C8=CC=CC=C8C5=O

Molecular Formula

C41H36N4O4

Molecular Weight

648.75

References & Citations

[1]Antony S, et al. Bisindenoisoquinoline bis-1,3-{ (5,6-dihydro-5,11-diketo-11H-indeno[1,2-c]isoquinoline) -6-propylamino}propane bis (trifluoroacetate) (NSC 727357), a DNA intercalator and topoisomerase inhibitor with antitumor activity. Mol Pharmacol. 2006 Sep;70 (3) :1109-20.