Telatinib (mesylate) (Standard)

Telatinib (mesylate) (Standard) is the analytical standard of Telatinib (mesylate) . This product is intended for research and analytical applications. Telatinib mesylate (Bay 57-9352 mesylate) is a potent and orally active VEGFR2, VEGFR3, PDGFα, and c-Kit inhibitor with IC50s of 6 nM, 4 nM, 15 nM and 1 nM, respectively[1].

Product Specifications

CAS Number

[332013-26-0]

Product Name Alternative

Bay 57-9352 (mesylate) (Standard)

UNSPSC

12352005

Target

C-Kit; PDGFR; Reference Standards; VEGFR

Related Pathways

Others; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

O=C(C1=NC=CC(COC2=NN=C(NC3=CC=C(Cl)C=C3)C4=C2OC=C4)=C1)NC.OS(=O)(C)=O

Molecular Formula

C21H20ClN5O6S

Molecular Weight

505.93

References & Citations

[1]Steeghs N, et al.Hypertension and rarefaction during treatment with telatinib, a small molecule angiogenesis inhibitor.Clin Cancer Res. 2008 Jun 1;14 (11) :3470-6.|[2][2] Sodani K, et al. Telatinib reverses chemotherapeutic multidrug resistance mediated by ABCG2 efflux transporter in vitro and in vivo. Biochem Pharmacol. 2014 May 1;89 (1) :52-61.