KU-2285

KU-2285 is an orally active fluorinated 2-nitroimidazole hypoxic cell radiosensitizer. KU-2285 has higher lipophilicity, superior sensitizing activity to Etanidazole (HY-116972), and lower neurotoxicity. KU-2285 can be used in research related to tumor diagnosis[1][2].

Product Specifications

CAS Number

[121077-11-0]

UNSPSC

12352005

Target

Biochemical Assay Reagents

Related Pathways

Others

Field of Research

Cancer

Smiles

O=C(NCCO)C(F)(F)CN1C=CN=C1[N+]([O-])=O

Molecular Formula

C8H10F2N4O4

Molecular Weight

264.19

References & Citations

[1]Sasai K, et al. A fluorinated 2-nitroimidazole, KU-2285, as a new hypoxic cell radiosensitizer. Int J Radiat Oncol Biol Phys. 1991 Jun;20 (6) :1249-54.|[2]Shibamoto Y, et al. A phase I study of a hypoxic cell sensitizer KU-2285 in combination with conventional radiotherapy. Radiother Oncol. 1996 Jul;40 (1) :55-8.