Galarubicin (hydrochloride)

Galarubicin hydrochloride (DA 125) is a novel Anthracycline derivative. Galarubicin hydrochloride shows high-affinity DNA binding and topoisomerase II inhibitory activities. Galarubicin hydrochloride induces Apoptosis. Galarubicin hydrochloride exerts cytotoxicity via JNK pathway. Galarubicin hydrochloride can be used in the research of hepatocellular carcinoma[1].

Product Specifications

CAS Number

[140637-82-7]

Product Name Alternative

DA 125

UNSPSC

12352005

Target

Apoptosis; DNA Alkylator/Crosslinker; Drug Derivative; JNK; Topoisomerase

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; MAPK/ERK Pathway; Others

Field of Research

Cancer

Smiles

F[C@H]([C@@H]([C@H](O)[C@H](C)O1)O)[C@]1([H])O[C@@H]2C3=C(O)C(C(C4=C(OC)C=CC=C4C5=O)=O)=C5C(O)=C3C[C@](C(COC(CCN)=O)=O)(O)C2.Cl

Molecular Formula

C30H33ClFNO13

Molecular Weight

670.03

References & Citations

[1]Kim SG, et al. DA-125, a novel anthracycline derivative showing high-affinity DNA binding and topoisomerase II inhibitory activities, exerts cytotoxicity via c-Jun N-terminal kinase pathway. Cancer Chemother Pharmacol. 2001 Jun;47 (6) :511-8.