Kahalalide F

Kahalalide F is a novel antitumor agent of marine origin. Kahalalide F can inhibit DNA synthesis. Kahalalide F cytotoxicity did not correlate with the expression level of the multidrug resistance MDR1 and of the tyrosine kinase HER2/NEU, and only slightly by the anti-apoptotic BCL-2 protein. Kahalalide F inhibits the PI3K-Akt signaling pathway by depleting ErbB3. Kahalalide F action was triggered rapidly by short pulse treatments. Kahalalide F induces cell death via oncosis preferentially in tumor cells. Kahalalide F can be used for the study of prostate cancer, breast cancer, vulval cancer, and non-small cell lung cancer[1][2][3].

Product Specifications

CAS Number

[149204-42-2]

UNSPSC

12352005

Target

Akt; DNA/RNA Synthesis; EGFR; PI3K

Related Pathways

Cell Cycle/DNA Damage; JAK/STAT Signaling; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

CC(C)CCCC(N[C@H](C(C)C)C(N[C@@H]([C@H](O)C)C(N[C@@H](C(C)C)C(N[C@H](C(C)C)C(N1[C@H](CCC1)C(N[C@@H](CCCN)C(N[C@@]([C@@H](C)CC)([H])C(N[C@H]2C(N[C@](C(N[C@](C(N[C@@H](CC3=CC=CC=C3)C(N/C(C(N[C@@H](C(C)C)C(O[C@@H]2C)=O)=O)=C/C)=O)=O)([H])C(C)C)=O)([H])[C@@H](C)CC)=O)=O)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C75H124N14O16

Molecular Weight

1477.87

References & Citations

[1]Suárez Y, et al. Kahalalide F, a new marine-derived compound, induces oncosis in human prostate and breast cancer cells. Mol Cancer Ther. 2003 Sep;2 (9) :863-72.|[2]Shilabin AG, Hamann MT. In vitro and in vivo evaluation of select kahalalide F analogs with antitumor and antifungal activities. Bioorg Med Chem. 2011 Nov 15;19 (22) :6628-32.|[3]Janmaat ML, et al. Kahalalide F induces necrosis-like cell death that involves depletion of ErbB3 and inhibition of Akt signaling. Mol Pharmacol. 2005 Aug;68 (2) :502-10.