Osutidine

Osutidine is a selective histamine H2 receptor antagonist, can effectively inhibit histamine-stimulated gastric acid secretion. Osutidine does not affect [14C]aminopyrine accumulation stimulated by carbachol or dibutyryl-cAMP. Osutidine is insurmountable and includes non-competitive inhibition. Osutidine can be used for the study of gastric mucosal injury[1][2].

Product Specifications

CAS Number

[140695-21-2]

UNSPSC

12352005

Target

Histamine Receptor

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Field of Research

Inflammation/Immunology

Smiles

OC(C1=CC=C(O)C=C1)CN/C(NS(C)(=O)=O)=N\CCSCC2=CC=C(CNC)O2

Molecular Formula

C19H28N4O5S2

Molecular Weight

456.58

References & Citations

[1]Inoie M, et al. Histamine H2-receptor antagonism of Osutidine, an anti-ulcer agent: studies on aminopyrine accumulation in isolated canine gastric mucosal cells. Jpn J Pharmacol. 1998 Nov;78 (3) :313-22. |[2]Tsuji S, et al. Effects of osutidine (T-593) and its enantiomers on gastric mucosal hemodynamics and mucosal integrity in anesthetized rats. Arzneimittelforschung. 2001 Jan;51 (1) :46-50.