Osutidine
Osutidine is a selective histamine H2 receptor antagonist, can effectively inhibit histamine-stimulated gastric acid secretion. Osutidine does not affect [14C]aminopyrine accumulation stimulated by carbachol or dibutyryl-cAMP. Osutidine is insurmountable and includes non-competitive inhibition. Osutidine can be used for the study of gastric mucosal injury[1][2].
Product Specifications
CAS Number
140695-21-2
UNSPSC
12352005
Target
Histamine Receptor
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Field of Research
Inflammation/Immunology
Smiles
OC(C1=CC=C(O)C=C1)CN/C(NS(C)(=O)=O)=N\CCSCC2=CC=C(CNC)O2
Molecular Formula
C19H28N4O5S2
Molecular Weight
456.58
References & Citations
[1]Inoie M, et al. Histamine H2-receptor antagonism of Osutidine, an anti-ulcer agent: studies on aminopyrine accumulation in isolated canine gastric mucosal cells. Jpn J Pharmacol. 1998 Nov;78 (3) :313-22. |[2]Tsuji S, et al. Effects of osutidine (T-593) and its enantiomers on gastric mucosal hemodynamics and mucosal integrity in anesthetized rats. Arzneimittelforschung. 2001 Jan;51 (1) :46-50.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
H2 Receptor
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