Atevirdine (mesylate)

Atevirdine (U 87201E) mesylate is a nonnucleoside reverse transcriptase (NNRT) inhibitor. Atevirdine mesylate can inhibit human immunodeficiency virus type 1 (HIV-1) with an IC50 of 0.06-1.6 μM. Atevirdine mesylate shows highly synergistic effects against Zidovudine/Didanosine-resistant clinical isolates of HIV-1 companied with Zidovudine (HY-17413) /Didanosine (Hy-B0249) . Atevirdine mesylate can be used for the research of AIDS[1].

Product Specifications

CAS Number

[138540-32-6]

Product Name Alternative

U 87201E (mesylate)

UNSPSC

12352005

Target

HIV; Reverse Transcriptase

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Inflammation/Immunology

Smiles

CS(=O)(O)=O.CCNC1=C(N2CCN(C(C3=CC4=C(C=CC(OC)=C4)N3)=O)CC2)N=CC=C1

Molecular Formula

C22H29N5O5S

Molecular Weight

475.56

References & Citations

[1]Campbell TB, et al. Inhibition of human immunodeficiency virus type 1 replication in vitro by the bisheteroarylpiperazine atevirdine (U-87201E) in combination with zidovudine or didanosine. J Infect Dis. 1993 Aug;168 (2) :318-26.