Lerisetron (Standard)
Lerisetron (Standard) is the analytical standard of Lerisetron. This product is intended for research and analytical applications. Lerisetron is a potent 5-HT3 antagonists and possess high-affinity binding for the 5-HT3 receptors with pKi value of 9.2. Lerisetron has a potent ability to inhibit the 5-HT-evoked reflex bradycardia in urethane-anesthetized rats[1].
Product Specifications
CAS Number
143257-98-1
UNSPSC
12352005
Target
5-HT Receptor; Reference Standards
Related Pathways
GPCR/G Protein; Neuronal Signaling; Others
Field of Research
Neurological Disease; Cardiovascular Disease; Cancer
Smiles
C1(N=C(N2CCNCC2)N3CC4=CC=CC=C4)=C3C=CC=C1
Molecular Formula
C18H20N4
Molecular Weight
292.39
References & Citations
[1]Orjales A, Mosquera R, Labeaga L, Rodes R. New 2-piperazinylbenzimidazole derivatives as 5-HT3 antagonists. Synthesis and pharmacological evaluation. J Med Chem. 1997;40 (4) :586-593.|[2]Jauregizar N, Calvo R, Suarez E, Quintana A, Raczka E, Lukas JC. Pharmacokinetics and pharmacological effect of lerisetron, a new 5-HT3 antagonist, in rats. J Pharm Sci. 2002;91 (1) :41-52.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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