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Zoniporide (hydrochloride hydrate) (Standard)

Zoniporide (hydrochloride hydrate) (Standard) is the analytical standard of Zoniporide (hydrochloride hydrate) . This product is intended for research and analytical applications. Zoniporide (CP-597396) hydrochloride hydrate is a potent and selective inhibitor of sodium-hydrogen exchanger type 1 (NHE-1) . Zoniporide hydrochloride hydrate inhibits human NHE-1 (IC50=14 nM), and has >150-fold selectivity versus other NHE isoforms. Zoniporide hydrochloride hydrate potently inhibits ex vivo NHE-1-dependent swelling of human platelets (IC50=59 nM) [1][2].

Product Specifications

Product Name Alternative

CP-597396 (hydrochloride hydrate) (Standard)

UNSPSC

12352005

Target

Na+/H+ Exchanger (NHE) ; Reference Standards

Related Pathways

Membrane Transporter/Ion Channel; Others

Field of Research

Cardiovascular Disease

Smiles

O=C(C1=C(C2CC2)N(C3=C4C=CC=NC4=CC=C3)N=C1)NC(N)=N.[H]Cl.[H]O[H]

Molecular Formula

C17H19ClN6O2

Molecular Weight

374.82

References & Citations

[1]Tracey WR, et al. Zoniporide: a potent and selective inhibitor of the human sodium-hydrogen exchanger isoform 1 (NHE-1) . Cardiovasc Drug Rev. 2003 Spring;21 (1) :17-32.|[2]Guzman-Perez A, et al. Discovery of zoniporide: a potent and selective sodium-hydrogen exchanger type 1 (NHE-1) inhibitor with high aqueous solubility. Bioorg Med Chem Lett. 2001 Mar 26;11 (6) :803-7.

Shipping Conditions

Room temperature

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-105064DR/

Scientific Category

Reference Standards

CAS Number

[863406-85-3]

Curated Selection

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