Zoniporide (mesylate)
Zoniporide mesylate (CP-597396 mesylate) is a potent and selective NHE-1 inhibitor with cardioprotective activity. Zoniporide inhibits 22Na+ uptake by human NHE-1-expressing fibroblasts in a concentration-dependent manner (IC50=14 nM) . Zoniporide inhibits platelet swelling in vitro with an IC50 of 0.059 μM. Zoniporide can be used in the study of cardiovascular disease[1].
Product Specifications
CAS Number
[249296-45-5]
Product Name Alternative
CP-597396 (mesylate)
UNSPSC
12352005
Target
Na+/H+ Exchanger (NHE)
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Cardiovascular Disease
Smiles
N=C(N)NC(C1=C(C2CC2)N(C3=C4C(N=CC=C4)=CC=C3)N=C1)=O.CS(=O)(O)=O
Molecular Formula
C18H20N6O4S
Molecular Weight
416.45
References & Citations
[1]Marala, et al. "Zoniporide: a potent and highly selective inhibitor of human Na+/H+ exchanger-1." European journal of pharmacology 451.1 (2002) : 37-41.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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