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Zoniporide (mesylate)

Zoniporide mesylate (CP-597396 mesylate) is a potent and selective NHE-1 inhibitor with cardioprotective activity. Zoniporide inhibits 22Na+ uptake by human NHE-1-expressing fibroblasts in a concentration-dependent manner (IC50=14 nM) . Zoniporide inhibits platelet swelling in vitro with an IC50 of 0.059 μM. Zoniporide can be used in the study of cardiovascular disease[1].

Product Specifications

CAS Number

249296-45-5

Product Name Alternative

CP-597396 (mesylate)

UNSPSC

12352005

Target

Na+/H+ Exchanger (NHE)

Related Pathways

Membrane Transporter/Ion Channel

Field of Research

Cardiovascular Disease

Smiles

N=C(N)NC(C1=C(C2CC2)N(C3=C4C(N=CC=C4)=CC=C3)N=C1)=O.CS(=O)(O)=O

Molecular Formula

C18H20N6O4S

Molecular Weight

416.45

References & Citations

[1]Marala, et al. "Zoniporide: a potent and highly selective inhibitor of human Na+/H+ exchanger-1." European journal of pharmacology 451.1 (2002) : 37-41.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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