Sabeluzole (Standard)

Sabeluzole (Standard) is the analytical standard of Sabeluzole. This product is intended for research and analytical applications. Sabeluzole (R 58735), a benzothiazol derivative, has antiischemic, antiepileptic, and cognitive-enhancing properties. Sabeluzole protects rat hippocampal neurons against NMDA- and glutamate-induced neurotoxicity via preventing tau expression. Sabeluzole enhances memory in rats, and prevents the amnesic effect of Chlordiazepoxide. Sabeluzole can be used fro research of Alzheimer's disease[1][2].

Product Specifications

CAS Number

[104383-17-7]

Product Name Alternative

R 58735 (Standard)

UNSPSC

12352005

Target

Reference Standards; Tau Protein

Related Pathways

Neuronal Signaling; Others

Field of Research

Neurological Disease

Smiles

CN(C1CCN(CC(O)COC2=CC=C(F)C=C2)CC1)C3=NC4=C(C=CC=C4)S3

Molecular Formula

C22H26FN3O2S

Molecular Weight

415.52

References & Citations

[1]Hlinák Z, et al. Sabeluzole improves social recognition and antagonizes chlordiazepoxide's effect on habituation in the rat. Psychopharmacology (Berl) . 1991;104 (4) :505-9. |[2]Uberti D, et al. Priming of cultured neurons with sabeluzole results in long-lasting inhibition of neurotoxin-induced tau expression and cell death. Synapse. 1997 Jun;26 (2) :95-103.