(Z) -SU14813

(Z) -SU14813 is an analog of SU14813 (HY-10501) . SU14813 is a multi-targeted receptor tyrosine kinases inhibitor with IC50s of 50, 2, 4, 15 nM for VEGFR2, VEGFR1, PDGFRβ and KIT[1].

Product Specifications

CAS Number

[452105-23-6]

UNSPSC

12352005

Target

Drug Derivative; PDGFR; VEGFR

Related Pathways

Others; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Solubility

10 mM in DMSO

Smiles

O=C1NC2=CC=C(C=C2/C1=C/C3=C(C(C(NC[C@@H](CN4CCOCC4)O)=O)=C(N3)C)C)F

Molecular Formula

C23H27FN4O4

Molecular Weight

442.48

References & Citations

[1]Patyna S, et al. SU14813: a novel multiple receptor tyrosine kinase inhibitor with potent antiangiogenic and antitumor activity. Mol Cancer Ther. 2006 Jul;5 (7) :1774-82.