AM580 (Standard)
AM580 (Standard) is the analytical standard of AM580. This product is intended for research and analytical applications. AM580 is a selective RARα agonist with IC50 and EC50 of 8 nM and 0.36 nM, respectively.
Product Specifications
CAS Number
[102121-60-8]
Product Name Alternative
CD336 (Standard) ; NSC608001 (Standard) ; Ro 40-6055 (Standard)
UNSPSC
12352005
Target
Autophagy; RAR/RXR; Reference Standards
Related Pathways
Autophagy; Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor
Field of Research
Cancer
Smiles
CC(CC1)(C)C2=C(C=CC(C(NC3=CC=C(C(O)=O)C=C3)=O)=C2)C1(C)C
Molecular Formula
C22H25NO3
Molecular Weight
351.44
References & Citations
[1]Gianní M, et al. AM580, a stable benzoic derivative of retinoic acid, has powerful and selective cyto-differentiating effects on acute promyelocytic leukemia cells. Blood. 1996 Feb 15;87 (4) :1520-31.|[2]Lu Y, et al. Mechanism of inhibition of MMTV-neu and MMTV-wnt1 induced mammary oncogenesis by RARalpha agonist AM580. Oncogene. 2010 Jun 24;29 (25) :3665-76.|[3]Bosch A, et al. Reversal by RARα agonist Am580 of c-Myc-induced imbalance in RARα/RARγ expression during MMTV-Myc tumorigenesis. Breast Cancer Res. 2012 Aug 24;14 (4) :R121.
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-10475R/
Scientific Category
Reference Standards
Available Sizes
Curated Selection
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