Torkinib (Standard)
Torkinib (Standard) is the analytical standard of Torkinib. This product is intended for research and analytical applications. Torkinib (PP 242) is a selective and ATP-competitive mTOR inhibitor with an IC50 of 8 nM[1]. PP242 inhibits both mTORC1 and mTORC2 with IC50s of 30 nM and 58 nM, respectively[2].
Product Specifications
CAS Number
1092351-67-1
Product Name Alternative
PP 242 (Standard)
UNSPSC
12352005
Target
Apoptosis; Autophagy; Mitophagy; mTOR; Reference Standards
Related Pathways
Apoptosis; Autophagy; Others; PI3K/Akt/mTOR
Field of Research
Cancer
Smiles
NC1=C2C(N(N=C2C3=CC4=C(N3)C=CC(O)=C4)C(C)C)=NC=N1
Molecular Formula
C16H16N6O
Molecular Weight
308.34
References & Citations
[1]Apsel B, et al. Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. Nat Chem Biol. 2008 Nov;4 (11) :691-9.|[2]Feldman ME, et al. Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2. PLoS Biol. 2009 Feb 10;7 (2) :e38.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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