BMS-577098

BMS-577098 is an orally active and ATP-competitive insulin-like growth factor-1 receptor (IGF-1R) inhibitor with an IC50 of 0.016 μM. BMS-577098 shows anti-tumor effect[1].

Product Specifications

CAS Number

[667402-44-0]

UNSPSC

12352005

Target

IGF-1R

Related Pathways

Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

COCCN(CC1)CCN1C2=CC(C)=C(N=C(C3=C(NC[C@@H](O)C4=CC=CC(Cl)=C4)C=CNC3=O)N5)C5=C2

Molecular Formula

C28H33ClN6O3

Molecular Weight

537.05

References & Citations

[1]Velaparthi U, et al. Insulin-like growth factor-1 receptor (IGF-1R) kinase inhibitors: SAR of a series of 3-[6- (4-substituted-piperazin-1-yl) -4-methyl-1H-benzimidazol-2-yl]-1H-pyridine-2-one. Bioorg Med Chem Lett. 2010 May 15;20 (10) :3182-5.