BMS-577098
BMS-577098 is an orally active and ATP-competitive insulin-like growth factor-1 receptor (IGF-1R) inhibitor with an IC50 of 0.016 μM. BMS-577098 shows anti-tumor effect[1].
Product Specifications
CAS Number
667402-44-0
UNSPSC
12352005
Target
IGF-1R
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
COCCN(CC1)CCN1C2=CC(C)=C(N=C(C3=C(NC[C@@H](O)C4=CC=CC(Cl)=C4)C=CNC3=O)N5)C5=C2
Molecular Formula
C28H33ClN6O3
Molecular Weight
537.05
References & Citations
[1]Velaparthi U, et al. Insulin-like growth factor-1 receptor (IGF-1R) kinase inhibitors: SAR of a series of 3-[6- (4-substituted-piperazin-1-yl) -4-methyl-1H-benzimidazol-2-yl]-1H-pyridine-2-one. Bioorg Med Chem Lett. 2010 May 15;20 (10) :3182-5.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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