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SKF-82958 (hydrobromide) (Standard)

SKF-82958 (hydrobromide) (Standard) is the analytical standard of SKF-82958 (hydrobromide) . This product is intended for research and analytical applications. SKF-82958 ((±) -SKF 82958) hydrobromide is a dopamine D1 receptor full agonist (K0.5=4 nM), displays selective for D1 over D2 receptors (K0.5=73 nM) . SKF-82958 hydrobromide induces dopamine D1 receptor-dependent adenylate cyclase activity in rat striatal membranes (EC50=491 nM) [1].

Product Specifications

Product Name Alternative

(±) -SKF-82958 (hydrobromide) (Standard) ; Chloro-APB (hydrobromide) (Standard)

UNSPSC

12352005

Target

Dopamine Receptor; Reference Standards

Related Pathways

GPCR/G Protein; Neuronal Signaling; Others

Field of Research

Neurological Disease

Smiles

OC1=C(O)C=C2C(C3=CC=CC=C3)CN(CC=C)CCC2=C1Cl.[H]Br

Molecular Formula

C19H21BrClNO2

Molecular Weight

410.73

References & Citations

[1]Mottola DM, et al. Conformational analysis of D1 dopamine receptor agonists: pharmacophore assessment and receptor mapping. J Med Chem. 1996;39 (1) :285-296.|[2]Haile CN, et al. The dopamine D (1) receptor agonist SKF-82958 serves as a discriminative stimulus in the rat. Eur J Pharmacol. 2000;388 (2) :125-131.|[3]Mayorga AJ, et al. Striatal and nigral D1 mechanisms involved in the antiparkinsonian effects of SKF 82958 (APB) : studies of tremulous jaw movements in rats. Psychopharmacology (Berl) . 1999;143 (1) :72-81.

Shipping Conditions

Room temperature

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-10435AR/

Scientific Category

Reference Standards

CAS Number

[74115-01-8]

Available Sizes

Curated Selection

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