Iso-WAY-260022

Iso-WAY-260022 (Compound 13R) is an orally active, brain-penetrant and selective norepinephrine transporter (hNET) inhibitor with an IC50 value of 140 nM. iso-WAY-260022 also shows inhibitory effects on human serotonin (hSERT) and dopamine transporters (hDAT) . iso-WAY-260022 inhibits norepinephrine reuptake and increases hypothalamic norepinephrine levels to regulate thermoregulatory center function. iso-WAY-260022 is promising for research of vasomotor symptoms, such as menopausal hot flushes, night sweats[1].

Product Specifications

CAS Number

[1214914-38-1]

Product Name Alternative

Iso-NRI-022

UNSPSC

12352005

Target

Dopamine Transporter; Serotonin Transporter

Related Pathways

Neuronal Signaling

Field of Research

Cardiovascular Disease

Smiles

C[C@H](N[C@@H](C1)C)CN1C[C@@H](C2=CC(OC(F)(F)F)=CC=C2)C3(CCCCC3)O

Molecular Formula

C21H31F3N2O2

Molecular Weight

400.48

References & Citations

[1]Gavrin LK, et al. Discovery of WAY-260022, a Potent and Selective Inhibitor of the Norepinephrine Transporter. ACS Med Chem Lett. 2010 Mar 25;1 (3) :91-5.