Rel-Talmapimod (hydrochloride)
Rel-Talmapimod (rel-SCIO-469) hydrochloride is an orally active and selective inhibitor of p38α MAPK with an IC50 of 9 nM. rel-Talmapimod hydrochloride inhibits the secretion of inflammatory factors (such as TNFα, IL-1β, IL-6, and VEGF) by suppressing the p38α MAPK pathway, and it also inhibits angiogenesis and osteoclast activation. rel-Talmapimod hydrochloride inhibits the growth of multiple myeloma cells and induces apoptosis. rel-Talmapimod hydrochloride can be used to study various hematological malignancies (such as multiple myeloma, myelodysplastic syndrome) [1][2][3][4].
Product Specifications
CAS Number
879132-01-1
Product Name Alternative
Rel-SCIO-469 (hydrochloride)
UNSPSC
12352005
Target
Apoptosis; Interleukin Related; p38 MAPK; TNF Receptor; VEGFR
Related Pathways
Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
CN(C)C(C(C(C1=C2)=CN(C)C1=CC(Cl)=C2C(N3[C@@H](CN([C@H](C3)C)CC4=CC=C(C=C4)F)C)=O)=O)=O.Cl
Molecular Formula
C27H31Cl2FN4O3
Molecular Weight
549.46
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-1; IL-6; p38α; p38β
Frequently Asked Questions
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