NecroX-5 (free base)
NecroX-5 free base is a derivative of the NecroX, reduces intracellular calcium concentration, and possesses anti-inflammatory and anti-cancer activity.
Product Specifications
CAS Number
[1120332-90-2]
UNSPSC
12352005
Target
Calcium Channel
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Cancer; Inflammation/Immunology
Smiles
O=S1(CCN(CC1)CC2=CC3=C(C(NCC4CCOCC4)=C2)NC(C5=CC=CC=C5)=C3)=O
Molecular Formula
C25H31N3O3S
Molecular Weight
453.60
References & Citations
[1]Thu VT, et al. NecroX-5 exerts anti-inflammatory and anti-fibrotic effects via modulation of the TNFα/Dcn/TGFβ1/Smad2 pathway in hypoxia/reoxygenation-treated rat hearts. Korean J Physiol Pharmacol. 2016 May;20 (3) :305-14.|[2]Park JH, et al. NecroX-5 prevents breast cancer metastasis by AKT inhibition via reducing intracellular calcium levels. Int J Oncol. 2017 Jan;50 (1) :185-192.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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