Sutezolid-13C4
Sutezolid-13C4 (PNU-100480-13C4) is 13C labeled Sutezolid. Sutezolid (PNU-100480), an orally active oxazolidinone antimicrobial agent, acts by inhibiting bacterial protein synthesis. Sutezolid has potent activity against mycobacteria, and is used for the research of drug-resistant tuberculosis[1][2].
Product Specifications
Product Name Alternative
PNU-100480-13C4; U-100480-13C4; PF-02341272-13C4
UNSPSC
12352005
Target
Antibiotic; Bacterial; Isotope-Labeled Compounds
Related Pathways
Anti-infection; Others
Applications
COVID-19-immunoregulation
Field of Research
Infection
Smiles
O=C(O[C@H]1CNC(C)=O)N(C1)C2=CC(F)=C(N3[13C][13C]S[13C][13C]3)C=C2
Molecular Formula
C12 13C4H12FN3O3S
Molecular Weight
349.32
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Barbachyn MR, et al. Identification of a novel oxazolidinone (U-100480) with potent antimycobacterial activity. J Med Chem. 1996;39 (3) :680-685.|[3]Nicole Salazar-Austin, et al. Sutezolid. In Kucers the Use of Antibiotics: A Clinical Review of Antibacterial, Antifungal, Antiparasitic, and Antiviral Drugs, Seventh Edition (pp. 2559-2563) . CRC Press.|[4]Zhu T, et al. Population pharmacokinetic/pharmacodynamic analysis of the bactericidal activities of sutezolid (PNU-100480) and its major metabolite against intracellular Mycobacterium tuberculosis in ex vivo whole-blood cultures of patients with pulmonary tuberculosis. Antimicrob Agents Chemother. 2014;58 (6) :3306-3311.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Frequently Asked Questions
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