(R) -DRF053

(R) -DRF053 is a CDK inhibitor. (R) -DRF053 inhibits Cdk5 and promotes the formation of ductal precursor β cells. (R) -DRF053 inhibits Dil-ox-LDL uptake and CD36 gene expression induced by advanced glycation end products (AGEs) in U937 cells[1][2].

Product Specifications

CAS Number

[1056016-06-8]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

CDK

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Others

Smiles

CC(C)N1C2=NC(N[C@@H](CO)CC)=NC(NC3=CC(C4=CC=CC=N4)=CC=C3)=C2N=C1

Molecular Formula

C23H27N7O

Molecular Weight

417.51

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Liu KC, et al. Inhibition of Cdk5 Promotes β-Cell Differentiation From Ductal Progenitors. Diabetes. 2018 Jan;67 (1) :58-70.|[2]Yashima H, et al. AGE-RAGE Axis Stimulates Oxidized LDL Uptake into Macrophages through Cyclin-Dependent Kinase 5-CD36 Pathway via Oxidative Stress Generation. Int J Mol Sci. 2020 Dec 4;21 (23) :9263.