Estramustine (Standard)
Estramustine (Standard) is the analytical standard of Estramustine. This product is intended for research and analytical applications. Estramustine is an antineoplastic agent. Estramustine depolymerizes microtnbules by binding to tubulin 1, exhibits antimitotic activity with an IC50 value of ~16 μM for mitosis of DU 145 cells. Estramustine blocks cells at mitosis in prostate tumor xenografts[1].
Product Specifications
CAS Number
[2998-57-4]
UNSPSC
12352005
Target
Microtubule/Tubulin; Mitosis; Reference Standards
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; Others
Field of Research
Cancer
Smiles
C[C@@]12[C@](CC[C@@H]2O)([H])[C@@]3([H])[C@@](CC1)([H])C4=CC=C(OC(N(CCCl)CCCl)=O)C=C4CC3
Molecular Formula
C23H31Cl2NO3
Molecular Weight
440.40
References & Citations
[1]Dahllöf B, et al. Estramustine depolymerizes microtubules by binding to tubulin. Cancer Res. 1993 Oct 1;53 (19) :4573-81.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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