Gardiquimod (hydrochloride)
Gardiquimod (hydrochloride) is an imidazoline TLR7/8 agonist. Gardiquimod (hydrochloride) inhibits HIV-1 infection of macrophages and activates peripheral blood mononuclear cells (PBMCs) . Gardiquimod (hydrochloride) specifically activates TLR7 at concentrations below 10 μM[1][2].
Product Specifications
CAS Number
2956183-81-4
UNSPSC
12352005
Target
HIV; Toll-like Receptor (TLR)
Related Pathways
Anti-infection; Immunology/Inflammation
Field of Research
Cancer; Infection
Smiles
OC(C)(CN1C(CNCC)=NC2=C1C3=C(C=CC=C3)N=C2N)C.Cl
Molecular Formula
C17H24ClN5O
Molecular Weight
349.86
References & Citations
[1]Buitendijk M, et al. Gardiquimod: a Toll-like receptor-7 agonist that inhibits HIV type 1 infection of human macrophages and activated T cells. AIDS Res Hum Retroviruses. 2013 Jun;29 (6) :907-18.|[2]Zhou Z, et al. TLR7/8 agonists promote NK-DC cross-talk to enhance NK cell anti-tumor effects in hepatocellular carcinoma. Cancer Lett. 2015 Dec 28;369 (2) :298-306.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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