Gardiquimod (diTFA) (Standard)
Gardiquimod (diTFA) (Standard) is the analytical standard of Gardiquimod (diTFA) . This product is intended for research and analytical applications. Gardiquimod diTFA is an imidazoline TLR7/8 agonist. Gardiquimod diTFA inhibits HIV-1 infection of macrophages and activated peripheral blood mononuclear cells (PBMCs) . Gardiquimod diTFA specifically activates TLR7 at concentrations below 10 μM.
Product Specifications
CAS Number
[1159840-61-5]
UNSPSC
12352005
Target
Reference Standards; Toll-like Receptor (TLR)
Related Pathways
Immunology/Inflammation; Others
Field of Research
Cancer
Smiles
OC(C)(C)CN1C(CNCC)=NC2=C1C3=CC=CC=C3N=C2N.FC(C(O)=O)(F)F.FC(C(O)=O)(F)F
Molecular Formula
C21H25F6N5O5
Molecular Weight
541.44
References & Citations
[1]Buitendijk M, et al. Gardiquimod: a Toll-like receptor-7 agonist that inhibits HIV type 1 infection of human macrophages and activated T cells. AIDS Res Hum Retroviruses. 2013 Jun;29 (6) :907-18.|[2]Ma F, et al. The TLR7 agonists imiquimod and gardiquimod improve DC-based immunotherapy for melanoma in mice. Cell Mol Immunol. 2010 Sep;7 (5) :381-8.|[3]Zhou Z, et al. TLR7/8 agonists promote NK-DC cross-talk to enhance NK cell anti-tumor effects in hepatocellular carcinoma. Cancer Lett. 2015 Dec 28;369 (2) :298-306.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Curated Selection
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