Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Canertinib (dihydrochloride) (Standard)

Canertinib (dihydrochloride) (Standard) is the analytical standard of Canertinib (dihydrochloride) . This product is intended for research and analytical applications. Canertinib dihydrochloride (CI-1033 dihydrochloride) is a potent and irreversible EGFR inhibitor; inhibits cellular EGFR and ErbB2 autophosphorylation with IC50s of 7.4 and 9 nM. Canertinib dihydrochloride is active against vaccinia virus respiratory infection in mice[1][2][3][4].

Product Specifications

CAS Number

289499-45-2

Product Name Alternative

CI-1033 dihydrochloride (Standard) ; PD-183805 dihydrochloride (Standard)

UNSPSC

12352005

Target

EGFR; Orthopoxvirus; Reference Standards

Related Pathways

Anti-infection; JAK/STAT Signaling; Others; Protein Tyrosine Kinase/RTK

Field of Research

Cancer; Infection

Smiles

C=CC(NC1=CC2=C(N=CN=C2C=C1OCCCN3CCOCC3)NC4=CC=C(C(Cl)=C4)F)=O.[H]Cl.[H]Cl

Molecular Formula

C24H27Cl3FN5O3

Molecular Weight

558.86

References & Citations

[1]Smaill JB, et al. Tyrosine kinase inhibitors. 17. Irreversible inhibitors of the epidermal growth factor receptor: 4- (phenylamino) quinazoline- and 4- (phenylamino) pyrido[3,2-d]pyrimidine-6-acrylamides bearing additional solubilizing functions. J Med Chem. 2000 Apr 6;43 (7) :1380-97.|[2]Djerf Severinsson EA, et al. The pan-ErbB receptor tyrosine kinase inhibitor canertinib promotes apoptosis of malignant melanoma in vitro and displays anti-tumor activity in vivo. Biochem Biophys Res Commun. 2011 Oct 28;414 (3) :563-8.|[3]McAndrews KM, et, al. Mechanisms associated with biogenesis of exosomes in cancer. Mol Cancer. 2019 Mar 30;18 (1) :52.|[4]Smee DF, et, al. Progress in the discovery of compounds inhibiting orthopoxviruses in animal models. Antivir Chem Chemother. 2008;19 (3) :115-24.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

alpha Adducin (ADD1) Rabbit Polyclonal Antibody
AP06003PU-N 100 µg

alpha Adducin (ADD1) Rabbit Polyclonal Antibody

Sign In for Pricing
View Details
MCSF Receptor (CSF1R) (734-744) Goat Polyclonal Antibody
AP22414PU-N 100 µg

MCSF Receptor (CSF1R) (734-744) Goat Polyclonal Antibody

Sign In for Pricing
View Details
Desmoglein-3 (Squamous Cell Marker) (DSG3/2839), CF488A conjugate, 0.1mg/mL
BNC882839-500 1x 500 µL

Desmoglein-3 (Squamous Cell Marker) (DSG3/2839), CF488A conjugate, 0.1mg/mL

Sign In for Pricing
View Details
Hybex™ Erlenmeyer Flask, threaded with cap, 250ml, case of 12
B3220-250 1 Each

Hybex™ Erlenmeyer Flask, threaded with cap, 250ml, case of 12

Sign In for Pricing
View Details
FIGNL1 (NM_001287492) Human Tagged ORF Clone
RG239283 10 µg

FIGNL1 (NM_001287492) Human Tagged ORF Clone

Sign In for Pricing
View Details
Human POTED activation kit by CRISPRa
GA117322 1 Kit

Human POTED activation kit by CRISPRa

Sign In for Pricing
View Details