BIIB042
BIIB042 is a potent, orally active, brain-penetrant, and selective γ-secretase modulator (GSM) . BIIB042 reduces Aβ42 and increases Aβ38 levels in cells. BIIB042 significantly reduces brain Aβ42 levels in CF-1 mice and Fischer rats, as well as plasma Aβ42 levels in cynomolgus monkeys. BIIB042 reduces Aβ42 levels and Aβ plaque burden in Tg2576 mice. BIIB042 can be used for alzheimer's disease (AD) research[1][2].
Product Specifications
CAS Number
1257396-73-8
UNSPSC
12352005
Target
Amyloid-β; γ-secretase
Related Pathways
Neuronal Signaling; Stem Cell/Wnt
Field of Research
Neurological Disease
Solubility
10 mM in DMSO
Smiles
OC([C@H](C)C(C=C1)=CC(C2=CC=C(C(F)(F)F)C=C2)=C1[C@H](N3CCC(C)CC3)C4=CC=C(F)C=C4)=O
Molecular Formula
C29H29F4NO2
Molecular Weight
499.54
References & Citations
[1]Peng H, et al. Discovery of BIIB042, a Potent, Selective, and Orally Bioavailable γ-Secretase Modulator. ACS Med Chem Lett. 2011 Aug 5;2 (10) :786-91.|[2]Scannevin RH, et al. BIIB042, a novel γ-secretase modulator, reduces amyloidogenic Aβ isoforms in primates and rodents and plaque pathology in a mouse model of Alzheimer's disease. Neuropharmacology. 2016 Apr;103:57-68.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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