BIIB042

BIIB042 is a potent, orally active, brain-penetrant, and selective γ-secretase modulator (GSM) . BIIB042 reduces Aβ42 and increases Aβ38 levels in cells. BIIB042 significantly reduces brain Aβ42 levels in CF-1 mice and Fischer rats, as well as plasma Aβ42 levels in cynomolgus monkeys. BIIB042 reduces Aβ42 levels and Aβ plaque burden in Tg2576 mice. BIIB042 can be used for alzheimer's disease (AD) research[1][2].

Product Specifications

CAS Number

[1257396-73-8]

UNSPSC

12352005

Target

Amyloid-β; γ-secretase

Related Pathways

Neuronal Signaling; Stem Cell/Wnt

Field of Research

Neurological Disease

Solubility

10 mM in DMSO

Smiles

OC([C@H](C)C(C=C1)=CC(C2=CC=C(C(F)(F)F)C=C2)=C1[C@H](N3CCC(C)CC3)C4=CC=C(F)C=C4)=O

Molecular Formula

C29H29F4NO2

Molecular Weight

499.54

References & Citations

[1]Peng H, et al. Discovery of BIIB042, a Potent, Selective, and Orally Bioavailable γ-Secretase Modulator. ACS Med Chem Lett. 2011 Aug 5;2 (10) :786-91.|[2]Scannevin RH, et al. BIIB042, a novel γ-secretase modulator, reduces amyloidogenic Aβ isoforms in primates and rodents and plaque pathology in a mouse model of Alzheimer's disease. Neuropharmacology. 2016 Apr;103:57-68.