MAO-B-IN-51
MAO-B-IN-51 (Compound 8f) is a selective, blood-brain-barrier permeable, orally active MAO-B inhibitor with an IC50 of 48．9 nM (MDS) . MAO-B-IN-51 enhances long-term memory[1].
Product Specifications
CAS Number
947540-06-9
UNSPSC
12352005
Target
Monoamine Oxidase
Related Pathways
Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O=C(C=1SC(=CC1)C2=NN(C(=C2)C(F)(F)F)C)N3CCC(O)CC3
Molecular Formula
C15H16F3N3O2S
Molecular Weight
359.37
References & Citations
[1]Kaplan AP, et al. Identification of 5- (1-Methyl-5- (trifluoromethyl) -1H-pyrazol-3-yl) thiophene-2-Carboxamides as Novel and Selective Monoamine Oxidase B Inhibitors Used to Improve Memory and Cognition. ACS Chem Neurosci. 2017 Dec 20;8 (12) :2746-2758.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MAO-B
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