BMS 182874 (hydrochloride)
BMS 182874 hydrochloride is an orallyactive, highly selective endothelin receptor (ETA receptor) antagonist, with IC50 value of 0.150 μM, Ki of 0.055 μM. BMS 182874 hydrochloride reduces the arterial pressure of Deoxycorticosterone acetate induced hypertension model in rats, and can be used for cardiovascular disease research[1].
Product Specifications
CAS Number
1215703-04-0
UNSPSC
12352005
Hazard Statement
H302
Target
Endothelin Receptor
Related Pathways
GPCR/G Protein
Field of Research
Metabolic Disease; Cardiovascular Disease
Smiles
O=S(C1=C2C=CC=C(C2=CC=C1)N(C)C)(NC3=C(C(C)=NO3)C)=O.Cl
Molecular Formula
C17H20ClN3O3S
Molecular Weight
381.88
Precautions
P264-P270-P330-P501
References & Citations
[1]Abdullaha M, et.al. Methoxy-naphthyl-Linked N-Benzyl Pyridinium Styryls as Dual Cholinesterase Inhibitors: Design, Synthesis, Biological Evaluation, and Structure-Activity Relationship. ACS Omega. 2023 May 9;8 (20) :17591-17608.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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