BMS 182874 (hydrochloride)

BMS 182874 hydrochloride is an orallyactive, highly selective endothelin receptor (ETA receptor) antagonist, with IC50 value of 0.150 μM, Ki of 0.055 μM. BMS 182874 hydrochloride reduces the arterial pressure of Deoxycorticosterone acetate (HY-B1472) induced hypertension model in rats, and can be used for cardiovascular disease research[1].

Product Specifications

CAS Number

[1215703-04-0]

UNSPSC

12352005

Hazard Statement

H302

Target

Endothelin Receptor

Related Pathways

GPCR/G Protein

Field of Research

Metabolic Disease; Cardiovascular Disease

Smiles

O=S(C1=C2C=CC=C(C2=CC=C1)N(C)C)(NC3=C(C(C)=NO3)C)=O.Cl

Molecular Formula

C17H20ClN3O3S

Molecular Weight

381.88

Precautions

P264-P270-P330-P501

References & Citations

[1]Abdullaha M, et.al. Methoxy-naphthyl-Linked N-Benzyl Pyridinium Styryls as Dual Cholinesterase Inhibitors: Design, Synthesis, Biological Evaluation, and Structure-Activity Relationship. ACS Omega. 2023 May 9;8 (20) :17591-17608.