ARP-100 (Standard)
ARP-100 (Standard) is the analytical standard of ARP-100. This product is intended for research and analytical applications. ARP-100 is a potent and selective matrix metalloproteinase MMP-2 inhibitor (IC50=12 nM) . ARP-100 interacts with S1＇ pocket of MMP-2 and shows anti-invasive properties in an in vitro model of invasion on matrigel. ARP-100 shows the less inhibitory activity towards MMP-1 (>50 μM), MMP-3 (4.5 μM), MMP-7 (>50 μM), and MMP-9 (0.2 μM) [1][2].
Product Specifications
CAS Number
704888-90-4
UNSPSC
12352005
Target
MMP; Reference Standards
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Cancer
Smiles
O=C(NO)CN(S(=O)(C1=CC=C(C2=CC=CC=C2)C=C1)=O)OC(C)C
Molecular Formula
C17H20N2O5S
Molecular Weight
364.42
References & Citations
[1]Rossello A, et al. New N-arylsulfonyl-N-alkoxyaminoacetohydroxamic acids as selective inhibitors of gelatinase A (MMP-2) . Bioorg Med Chem. 2004 May 1;12 (9) :2441-50.|[2]Tuccinardi T, et al. Amber force field implementation, molecular modelling study, synthesis and MMP-1/MMP-2 inhibition profile of (R) - and (S) -N-hydroxy-2- (N-isopropoxybiphenyl-4-ylsulfonamido) -3-methylbutanamides. Bioorg Med Chem. 2006 Jun 15;14 (12) :4260-76.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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