Enzastaurin (Standard)
Enzastaurin (Standard) is the analytical standard of Enzastaurin. This product is intended for research and analytical applications. Enzastaurin (LY317615) is a potent and selective PKCβ inhibitor with an IC50 of 6 nM, showing 6- to 20-fold selectivity over PKCα, PKCγ and PKCε[1].
Product Specifications
CAS Number
170364-57-5
Product Name Alternative
LY317615 (Standard)
UNSPSC
12352005
Target
Apoptosis; Autophagy; PKC; Reference Standards
Related Pathways
Apoptosis; Autophagy; Epigenetics; Others; TGF-beta/Smad
Field of Research
Cancer
Smiles
O=C(C(C1=CN(C)C2=C1C=CC=C2)=C3C4=CN(C5CCN(CC6=NC=CC=C6)CC5)C7=C4C=CC=C7)NC3=O
Molecular Formula
C32H29N5O2
Molecular Weight
515.61
References & Citations
[1]Rovedo MA, et al. Inhibition of glycogen synthase kinase-3 increases the cytotoxicity of enzastaurin. J Invest Dermatol, 2011, 131 (7), 1442-1449.|[2]Podar K, et al. Targeting PKC in multiple myeloma: in vitro and in vivo effects of the novel, orally available small-molecule inhibitor enzastaurin (LY317615.HCl) . Blood, 2007, 109 (4), 1669-1677.|[3]Graff JR, et al. The protein kinase Cbeta-selective inhibitor, Enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts. Cancer Res, 2005, 65 (16)
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
Frequently Asked Questions
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