NGD 94-1 (dimaleate)

NGD 94-1 (dimaleate) is a potent and selective dopamine D4 receptor antagonist. NGD 94-1 (dimaleate) shows high affinity for the cloned human D4.2 receptor (Ki = 3.6 nM) . NGD 94-1 (dimaleate) modulates the cognitive functions of the frontostriatal system and regulates dopaminergic transmission in Phencyclidine (PCP) -induced monkeys. NGD 94-1 (dimaleate) can be used for neurological disease research[1][2].

Product Specifications

CAS Number

[179333-18-7]

UNSPSC

12352005

Target

Dopamine Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Solubility

10 mM in DMSO

Smiles

O=C(O)/C=C\C(O)=O.O=C(O)/C=C\C(O)=O.C1(N2CCN(CC3=CN=C(C4=CC=CC=C4)N3)CC2)=NC=CC=N1

Molecular Formula

C26H28N6O8

Molecular Weight

552.54

References & Citations

[1]Jentsch JD, et al. Dopamine D4 receptor antagonist reversal of subchronic phencyclidine-induced object retrieval/detour deficits in monkeys. Psychopharmacology (Berl) . 1999 Feb;142 (1) :78-84.|[2]Tallman JF, et al. I. NGD 94-1: identification of a novel, high-affinity antagonist at the human dopamine D4 receptor. J Pharmacol Exp Ther. 1997 Aug;282 (2) :1011-9.|[3]Gazi L, et al. NGD 94-1 as an agonist at human recombinant dopamine D4.4 receptors expressed in HEK293 cells. Eur J Pharmacol. 1999 May 21;372 (3) :R9-10.