Nanaomycin A (Standard)

Nanaomycin A (Standard) is the analytical standard of Nanaomycin A. This product is intended for research and analytical applications. Nanaomycin A is the first selective DNMT3B inhibitor with an IC50 of 500 nM. Nanaomycin A, a quinone antibiotics, reactivates silenced tumor suppressor genes in human cancer cells[1]. Nanaomycin A inhibits in vitro growth of the human malaria parasite Plasmodium falciparum with an IC80 value of 33.1 nM[2].

Product Specifications

CAS Number

[52934-83-5]

UNSPSC

12352005

Target

Antibiotic; DNA Methyltransferase; Parasite; Reference Standards

Related Pathways

Anti-infection; Epigenetics; Others

Field of Research

Cancer; Infection

Smiles

O=C(O)C[C@H]1CC(C(C2=C3C(O)=CC=C2)=O)=C(C3=O)[C@H](C)O1

Molecular Formula

C16H14O6

Molecular Weight

302.28

References & Citations

[1]Kuck D, et al.Nanaomycin A selectively inhibits DNMT3B and reactivates silenced tumor suppressor genes in human cancer cells.Mol Cancer Ther. 2010 Nov;9 (11) :3015-23.|[2]Tanaka Y, et al.Heme-dependent radical generation: possible involvement in antimalarial action of non-peroxide microbial metabolites, nanaomycin A and radicicol.J Antibiot (Tokyo) . 1999 Oct;52 (10) :880-8.