Trimetrexate (glucuronate) (Standard)

Trimetrexate (glucuronate) (Standard) is the analytical standard of Trimetrexate (glucuronate) . This product is intended for research and analytical applications. Trimetrexate glucuronate (NSC 352122) is a folic acid antagonist. Trimetrexate glucuronate affects DNA and RNA synthesis by inhibiting dihydrofolate reductase and preventing the synthesis of purine nucleotides and thymidylate. Trimetrexate glucuronate has potential antitumour activity and can also be used to inhibit Pneumocystis carinii pneumonia[1][2].

Product Specifications

CAS Number

[82952-64-5]

Product Name Alternative

CI-898 (glucuronate) (Standard)

UNSPSC

12352005

Target

Antifolate; Bacterial; Reference Standards

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; Others

Field of Research

Cancer; Infection

Smiles

O=C[C@@H]([C@H]([C@@H]([C@@H](C(O)=O)O)O)O)O.NC1=NC(N)=C2C(C)=C(CNC3=CC(OC)=C(OC)C(OC)=C3)C=CC2=N1

Molecular Formula

C25H33N5O10

Molecular Weight

563.56

References & Citations

[1]R C Jackson, et al. Biochemical pharmacology of the lipophilic antifolate, trimetrexate. Adv Enzyme Regul. 1984;22:187-206.|[2]P J Harris, et al. Trimetrexate glucuronate associated with anti-Kaposi sarcoma effect. AIDS Patient Care STDS. 1996 Oct;10 (5) :280-1.