C-021 (dihydrochloride) (Standard)

C-021 (dihydrochloride) (Standard) is the analytical standard of C-021 (dihydrochloride) . This product is intended for research and analytical applications. C-021 dihydrochloride is a potent CC chemokine receptor-4 (CCR4) antagonist. C-021 dihydrochloride potently inhibits functional chemotaxis in human and mouse with IC50s of 140 nM and 39 nM, respectively. C-021 dihydrochloride effectively prevents human CCL22-derived [35S]GTPγS from binding to the receptor with an IC50 of 18 nM[1].

Product Specifications

CAS Number

[1784252-84-1]

UNSPSC

12352005

Target

CCR; Reference Standards

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Others

Field of Research

Inflammation/Immunology

Smiles

COC1=CC2=NC(N3CCC(N4CCCCC4)CC3)=NC(NC5CCCCCC5)=C2C=C1OC.[H]Cl.[H]Cl

Molecular Formula

C27H43Cl2N5O2

Molecular Weight

540.57

References & Citations

[1]Yokoyama K, et al. Potent and orally bioavailable CCR4 antagonists: Synthesis and structure-activity relationship study of 2-aminoquinazolines. Bioorg Med Chem. 2009 Jan 1;17 (1) :64-73.|[2]Matthew McMillin, et al. Neuronal CCL2 is upregulated during hepatic encephalopathy and contributes to microglia activation and neurological decline. J Neuroinflammation. 2014 Jul 10;11:121.