BMS-645737
BMS-645737 is an orally active, selective FGF receptor-1 and VEGF receptor-2 inhibitor. BMS-645737 selectively and competitively inhibits both VEGFR-2 and FGFR-1 tyrosine kinases. BMS-645737 has anti-angiogenic activity. BMS-645737 induces lesions in the incisor teeth[1].
Product Specifications
CAS Number
[651744-16-0]
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
FGFR; VEGFR
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cardiovascular Disease; Inflammation/Immunology
Smiles
N=1N=C(OC1C2=CN3N=CN=C(NC=4C=NC=5NC(=CC5C4)C)C3=C2C(C)C)C
Molecular Formula
C20H20N8O
Molecular Weight
388.44
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]Fletcher AM, et al. Incisor degeneration in rats induced by vascular endothelial growth factor/fibroblast growth factor receptor tyrosine kinase inhibition. Toxicol Pathol. 2010 Feb;38 (2) :267-79.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
FGFR1; VEGFR2/KDR/Flk-1
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
041755-APC 200 µL
SIRPD, ID (SIRPD, PTPNS1L2, Signal-regulatory protein delta, Protein tyrosine phosphatase non-receptor type substrate 1-like 2) (APC) discontinued
Ask
View Details 
036536-PE 200 µL
HHIP, NT (HHIP, HIP, Hedgehog-interacting protein) (PE) discontinued
Ask
View Details 
041340-ML750 100 µL
RWDD1, NT (RWDD1, DFRP2, RWD domain-containing protein 1, DRG family-regulatory protein 2) (MaxLight 750) discontinued
Ask
View Details