BMS-645737

BMS-645737 is an orally active, selective FGF receptor-1 and VEGF receptor-2 inhibitor. BMS-645737 selectively and competitively inhibits both VEGFR-2 and FGFR-1 tyrosine kinases. BMS-645737 has anti-angiogenic activity. BMS-645737 induces lesions in the incisor teeth[1].

Product Specifications

CAS Number

[651744-16-0]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

FGFR; VEGFR

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cardiovascular Disease; Inflammation/Immunology

Smiles

N=1N=C(OC1C2=CN3N=CN=C(NC=4C=NC=5NC(=CC5C4)C)C3=C2C(C)C)C

Molecular Formula

C20H20N8O

Molecular Weight

388.44

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Fletcher AM, et al. Incisor degeneration in rats induced by vascular endothelial growth factor/fibroblast growth factor receptor tyrosine kinase inhibition. Toxicol Pathol. 2010 Feb;38 (2) :267-79.