FPL64176 (Standard)

FPL64176 (Standard) is the analytical standard of FPL64176. This product is intended for research and analytical applications. FPL64176, a nondihydropyridine compound, is a potent agonist of L-type Ca2+ channels with an EC50 value of 16 nM[1][2].

Product Specifications

CAS Number

[120934-96-5]

UNSPSC

12352005

Target

Calcium Channel; Reference Standards

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling; Others

Field of Research

Cardiovascular Disease

Smiles

O=C(C1=C(C)NC(C)=C1C(C2=CC=CC=C2CC3=CC=CC=C3)=O)OC

Molecular Formula

C22H21NO3

Molecular Weight

347.41

References & Citations

[1]Zheng W, Rampe D, Triggle DJ. Pharmacological, radioligand binding, and electrophysiological characteristics of FPL 64176, a novel nondihydropyridine Ca2+ channel activator, in cardiac and vascular preparations. Mol Pharmacol. 1991 Nov;40 (5) :734-41.|[2]Baxter AJ, Dixon J, Ince F, Manners CN, Teague SJ. Discovery and synthesis of methyl 2,5-dimethyl-4-[2- (phenylmethyl) benzoyl]-1H-pyrrole-3-carboxylate (FPL 64176) and analogues: the first examples of a new class of calcium channel activator. J Med Chem.