S32826 (disodium) (Standard)
S32826 (disodium) (Standard) is the analytical standard of S32826 (disodium) . This product is intended for research and analytical applications. S32826 disodium is a potent autotaxin inhibitor, with an IC50 of 8.8 nM. S32826 disodium shows similar inhibitory effects at various autotaxin isoforms (α, β and γ) . S32826 disodium inhibits LPA release from adipocytes[1].
Product Specifications
CAS Number
1103672-43-0
UNSPSC
12352005
Target
Phosphodiesterase (PDE) ; Reference Standards
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Inflammation/Immunology
Smiles
O=C(CCCCCCCCCCCCC)NC1=CC=C(CP(O[Na])(O[Na])=O)C=C1
Molecular Formula
C21H34NNa2O4P
Molecular Weight
441.45
References & Citations
[1]Ferry G, et, al. S32826, a nanomolar inhibitor of autotaxin: discovery, synthesis and applications as a pharmacological tool. J Pharmacol Exp Ther. 2008 Dec;327 (3) :809-19.|[2]Honjo M, et, al. Role of the Autotaxin-LPA Pathway in Dexamethasone-Induced Fibrotic Responses and Extracellular Matrix Production in Human Trabecular Meshwork Cells. Invest Ophthalmol Vis Sci. 2018 Jan 1;59 (1) :21-30.|[3]Iyer P, et, al. Autotaxin-lysophosphatidic acid axis is a novel molecular target for lowering intraocular pressure. PLoS One. 2012;7 (8) :e42627.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
Frequently Asked Questions
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