Monomethyl fumarate-d2

Monomethyl fumarate-d2 is a deuterium labeled Monomethyl fumarate (HY-103252) . Monomethyl fumarate, an active metabolite of Dimethyl fumarate (DMF) (HY-17363), is a potent GPR109A agonist. Monomethyl fumarate has the potential for multiple neuroprotective pathways and other models of retinal disease[1][2][3].

Product Specifications

CAS Number

[253122-44-0]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Drug Metabolite; GPR109A; Isotope-Labeled Compounds

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease; Others

Field of Research

Inflammation/Immunology; Neurological Disease

Purity

98.2

Smiles

COC(/C([2H])=C([2H])/C(O)=O)=O

Molecular Formula

C5H4D2O4

Molecular Weight

132.11

Precautions

H302, H315, H319, H335

References & Citations

[1]Tang H, et al. The psoriasis drug monomethylfumarate is a potent nicotinic acid receptor agonist. Biochem Biophys Res Commun. 2008 Oct 31;375 (4) :562-5. |[2]Jiang D, et al. Monomethyl Fumarate Protects the Retina From Light-Induced Retinopathy. Invest Ophthalmol Vis Sci. 2019 Mar 1;60 (4) :1275-1285. |[3]Sghaier R, et al. Dimethyl fumarate and monomethyl fumarate attenuate oxidative stress and mitochondrialalterations leading to oxiapoptophagy in 158N murine oligodendrocytes treated with 7β-hydroxycholesterol. J Steroid Biochem Mol Biol. 2019 Nov;194:105432.