Monomethyl fumarate-d2
Monomethyl fumarate-d2 is a deuterium labeled Monomethyl fumarate. Monomethyl fumarate, an active metabolite of Dimethyl fumarate (DMF) (HY-17363), is a potent GPR109A agonist. Monomethyl fumarate has the potential for multiple neuroprotective pathways and other models of retinal disease[1][2][3].
Product Specifications
CAS Number
253122-44-0
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Drug Metabolite; GPR109A; Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease; Others
Field of Research
Inflammation/Immunology; Neurological Disease
Purity
98.2
Smiles
COC(/C([2H])=C([2H])/C(O)=O)=O
Molecular Formula
C5H4D2O4
Molecular Weight
132.11
Precautions
H302, H315, H319, H335
References & Citations
[1]Tang H, et al. The psoriasis drug monomethylfumarate is a potent nicotinic acid receptor agonist. Biochem Biophys Res Commun. 2008 Oct 31;375 (4) :562-5. |[2]Jiang D, et al. Monomethyl Fumarate Protects the Retina From Light-Induced Retinopathy. Invest Ophthalmol Vis Sci. 2019 Mar 1;60 (4) :1275-1285. |[3]Sghaier R, et al. Dimethyl fumarate and monomethyl fumarate attenuate oxidative stress and mitochondrialalterations leading to oxiapoptophagy in 158N murine oligodendrocytes treated with 7β-hydroxycholesterol. J Steroid Biochem Mol Biol. 2019 Nov;194:105432.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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