Monomethyl fumarate (Standard)

Monomethyl fumarate (Standard) is the analytical standard of Monomethyl fumarate. This product is intended for research and analytical applications. Monomethyl fumarate, an active metabolite of Dimethyl fumarate (DMF), is a potent GPR109A agonist. Monomethyl fumarate has the potential for multiple neuroprotective pathways and other models of retinal disease[1][2][3].

Product Specifications

CAS Number

[2756-87-8]

UNSPSC

12352211

Target

Drug Metabolite; GPR109A; Reference Standards

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease; Others

Field of Research

Inflammation/Immunology; Neurological Disease

Smiles

O=C(OC)/C=C/C(O)=O

Molecular Formula

C5H6O4

Molecular Weight

130.10

References & Citations

[1]Tang H, et al. The psoriasis drug monomethylfumarate is a potent nicotinic acid receptor agonist. Biochem Biophys Res Commun. 2008 Oct 31;375 (4) :562-5.|[2]Jiang D, et al. Monomethyl Fumarate Protects the Retina From Light-Induced Retinopathy. Invest Ophthalmol Vis Sci. 2019 Mar 1;60 (4) :1275-1285.|[3]Sghaier R, et al. Dimethyl fumarate and monomethyl fumarate attenuate oxidative stress and mitochondrialalterations leading to oxiapoptophagy in 158N murine oligodendrocytes treated with 7β-hydroxycholesterol. J Steroid Biochem Mol Biol. 2019 Nov;194:105432.