TCPOBOP (Standard)

TCPOBOP (Standard) is the analytical standard of TCPOBOP. This product is intended for research and analytical applications. TCPOBOP is a constitutive androstane receptor (CAR) agonist that induces robust hepatocyte proliferation and hepatomegaly without any liver injury or tissue loss[1]. TCPOBOP attenuates Fas-induced murine liver injury by altering Bcl-2 proteins[2].

Product Specifications

CAS Number

[76150-91-9]

UNSPSC

12352005

Target

Bcl-2 Family; Reference Standards

Related Pathways

Apoptosis; Others

Field of Research

Cancer

Smiles

ClC1=CN=C(OC2=CC=C(OC3=NC=C(Cl)C=C3Cl)C=C2)C(Cl)=C1

Molecular Formula

C16H8Cl4N2O2

Molecular Weight

402.06

References & Citations

[1]Bhushan B, et al. TCPOBOP-Induced Hepatomegaly and Hepatocyte Proliferation are Attenuated by Combined Disruption of MET and EGFR Signaling. Hepatology. 2019 Apr;69 (4) :1702-1718.|[2]Baskin-Bey ES, et al. Constitutive androstane receptor (CAR) ligand, TCPOBOP, attenuates Fas-induced murine liver injury by altering Bcl-2 proteins. Hepatology. 2006 Jul;44 (1) :252-62.